The Colorectal cancer RISk Prediction (CRISP) trial: a randomised controlled trial of a decision support tool for risk-stratified colorectal cancer screening

JD Emery; MA Jenkins; S Saya; P Chondros; J Oberoi; S Milton; K Novy; E Habgood; N Karnchanachari; M Pirotta; L Trevena; A Bickerstaffe; R De Abreu Lourenço; A Crothers; DA Ouakrim; L Flander; JG Dowty; FM Walter; M Clark; S Doncovio; D Etemadmoghadam; F George; F Macrae; I Winship; JG McIntosh

Journal article

The Colorectal cancer RISk Prediction (CRISP) trial: a randomised controlled trial of a decision support tool for risk-stratified colorectal cancer screening

JD Emery, MA Jenkins, S Saya, P Chondros, J Oberoi, S Milton, K Novy, E Habgood, N Karnchanachari, M Pirotta, L Trevena, A Bickerstaffe, R De Abreu Lourenço, A Crothers, DA Ouakrim, L Flander, JG Dowty, FM Walter, M Clark, S Doncovio Show all

British Journal of General Practice | ROYAL COLL GENERAL PRACTITIONERS | Published : 2023

DOI: 10.3399/BJGP.2022.0480

Abstract

Background A risk-stratified approach to colorectal cancer (CRC) screening could result in a more acceptable balance of benefits and harms, and be more cost-effective. Aim To determine the effect of a consultation in general practice using a computerised risk assessment and decision support tool (Colorectal cancer RISk Prediction, CRISP) on risk-appropriate CRC screening. Design and setting Randomised controlled trial in 10 general practices in Melbourne, Australia, from May 2017 to May 2018. Method Participants were recruited from a consecutive sample of patients aged 50–74 years attending their GP. Intervention consultations included CRC risk assessment using the CRISP tool and discussion ..

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University of Melbourne Researchers

Jon Emery Author

Mark Jenkins Author

Sibel Saya Author

Patty Chondros Author

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Grants

Awarded by Cancer Australia

Funding Acknowledgements

This trial was funded by a National Health and Medical Research Council (NHMRC) project grant (reference: AP1121104), Centre for Research Excellence grant (reference: APP1042021), and a Victorian Cancer Agency grant (reference: HSR15019). Jon D Emery is supported by an NHMRC Investigator grant (reference: APP1195302). Mark A Jenkins is supported by an NHMRC Investigator grant (reference: APP1195099). The trial was supported by the Cancer Australia funded Primary Care Collaborative Cancer Clinical Trials Group (PC4). The trial is affiliated to the CanTest Collaborative (funded by Cancer Research UK; reference: C8640/A23385) of which Jon D Emery is an Associate Director and Fiona M Walter is Director. The funding sources had no role in the conduct or interpretation of the trial results.